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Cleaning Validation Glossary

Gas Chromatography (GC)

Analyzing gas mixtures

Gas chromatography (GC) is used to determine the indidual compontents of a mixed substance that is evaporated. The sample is injected and vaporized following a predetermined temperature program based on the published monograph of the analyte. A carrier gas (an inert gas such as helium, nitrogen, or hydrogen) is used to mobilize the gas produced by the substance being analyzed. The signal is meassured as a peak in relation to time. USP <621>,Chromatography, includes additional information and resources for GC and other chromatography assays.

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